COMPOSITION
Each
tablet contains
Isoxsuprene
HCl 10mg
INTRODUCTION:
Isox
contains Isoxsuprine an adrenaline derivative vasodilators tocolytic drug.
PHARMACODYNAMIC
Isoxsuprine
is a - receptor antagonist, b-adrenergic agonist that causes direct relaxation of
uterine and vascular smooth muscle. Its vasodilating actions are greater on the
arteries supplying skeletal muscle than on those supplying skin. It is used in
the treatment of peripheral vascular disease and in premature labour.
Isoxsuprine also produces positive inotropic and positive chronotropic effects.
PHARMACOKINETICS:
Isoxsuprine
is well absorbed from the GI tract. The peak plasma concentration occurs about
1 hour after oral administration. Plasma half life is about 1.5 hour and is excreted
in the urine mainly as conjugates. Isoxsuprine inhibits uterine contraction.
INDICATION:
1)
premature labors
2)
habitual abortion
3)
threatened
abortion
4)
night leg cramp (
co-prescribe with tranquilo sedative drugs like diazepam. Isox enhance proper
circulation.)
( 2
tablets QID for 7-10days followed by 1 tablet TID upto 2-3 weeks)
5)
intermittent
claudication
DOSAGE:
Initially loading dose 2 tabs 3-4 times daily
for 3 weeks followed by 1 tsb 3 times continues till delivery.
ADVERSE EFFECT: Isoxsuprine may cause trasient flushing, hypotension,
tachycardia, rashes, gastrointestinal disturbances. Maternal pulmonary oedema
and fetal tachycardia have been reported following IV administration in
premature labour.
PRECAUTION
In
women being treated for premature labour, the risk of pulmonary oedema needs to
be calculated.
CONTRAINDICATION:
After
recent arterial haemorrhage, immediately after post partum, premature labour
with infection.
