COMPOSITION
DIF 50 TAB
Each
tablet contains
Diclofenac
Potassium 50mg
DIF 100 TAB
Each
tablet contains
Diclofenac
Potassium 100mg
DESCRIPTION
DIF contains Potassium salt of Diclofenac, a nonsteroidal anti-inflammatory
drug (NSAID). In pharmacologic studies, Diclofenac has shown anti-inflammatory,
analgesic, and antipyretic activity.
PHARMACOLIGY
Pharmacodynamics
DIF reduces Prostaglandin (PG)
synthesis in these two steps:
1.
It inhibits
cyclo–oxygenase (COX) enzyme which is the first step in prostaglandin synthesis.
2.
It also reduces intercellular concentration of free
arachidonate in leucocyte. These are precursors of prostaglandin synthesis.
Pharmacokinetics
Under
fasting condition, diclofenac is completely absorbed from the gastrointestinal
tract. However, due to first-pass metabolism, only about 50% of the absorbed
dose is systemically available.
Plasma
concentrations of diclofenac decline from peak levels in a bi-exponential
fashion, with the terminal phase having a half-life of approximately 2 hours.
More than 99% of diclofenac is reversibly bound to human plasma albumin.
INDICATIONS
Muscular
skeletal diseases
DIF is used to
control acute and chronic painful inflammatory diseases of muscular skeletal
system like
-
Rheumatoid Arthritis
-
Osteoarthritis
-
Ankylosing Spondylitis
-
Cervical Spondylitis
-
Injury
-
Fractures
-
Sprains
-
Bursitis
-
Tennis elbow
-
Gout
-
Muscle Pain
-
Neurogenic pain like Sciatica
-
Chronic Backache
-
Slipped intervertebral Disc
-
To control post operative pain
-
Acute renal colic
-
Acute Biliary colic
-
Headache
-
Dental Pain
Dentistry
DIF can be used
in following conditions:
-
Pain after tooth extraction.
-
Painful tooth conditions such as cavity, apical abscess
etc.
Gynecology and Obstetrics
-
To control pain in dysmenorrhea.
-
Postpartum Uterine pain.
-
Pain after surgery, copper T insertion etc.
DOSAGE AND ADMINISTRATION
Analgesia and Primary Dysmenorrhoea: 50 mg TID.
Osteoarthritis:
100 to 150 mg/ day:
Rheumatoid Arthritis: 100 to 200 mg/ day
Ankylosing Spondylitis: 100 to 125 mg/ day
CONTRAINDICATIONS
GI bleeding, active peptic
ulcer NSAID induced allergic asthma.
ADVERSE EFFECTS
Nausea, vomiting, Epigastric
discomfort, skin rash, peptic ulcer, fluid retention, oedema, impairment of hepatic function (rarely).
WARNING AND PRECAUTIONS
Impairment of hepatic, renal
or cardiac function, GI disorders, children.
DRUG INTERACTIONS:
·
Increased blood
levels of lithium and digoxin, leading to enhanced efficacy and possible
toxicity.
·
Inhibits efficacy
of diuretics but enhances efficacy of potassium sparing diuretics.
·
Toxicity of
methotrexate enhances.
·
Increase
nephrotoxicity effect when administered with cyclosporin.
