TRYSIN
COMPOSITION:
Each enteric coated
tablet contains:
Trypsin and
chymotrypsin eqvt to 100,000 units of
enzymatic activity.
PHARMACOKINETICS
Trysin is released
and absorbed in the small intestine when given in enteric coated form passing
the destructive activity of the acid pepsin of the stomach.
MECHANISM OF ACTION :
PROTEOLYTIC
ACTION: Trysin causes
proteolysis by breaking down proteins into peptones and into smaller fragments
called amino acid. The peptones and amino acid are absorbed by the cells of the
small intestine.
FIBRINOLYTIC ACTION: Trysin facilitates the action of fibrinolytic
agent “plasmin” that restores circulation, resolving edema and hematoma. It
promotes phagocytosis to remove the debris.
VASCULAR RESPONSE MODULATOR: The drug increases the levels of APR’s (Acute
Phase Reactant), which minimize the necrotic damage and scarring.
MODULATION OF INFLAMMATION: The drug reduces the proinflammatory
mediators. The fibrin blocked microcirculation could be cleared earlier by the
administration of the enzyme, and hence the inflammation resolves quicker and
healing commences at an early stage.
WARNINGS
The tablet must be
swallowed, whole to preserve the enteric coating, since damage to enteric
coated rapidly causes loss of potency.
ADVERSE EFFECTS:
Generally, it is
well tolerated. However, certain effects can be seen like occasional gastric
disturbances. An increased intraocular pressure, corneal oedema, striation and
uveitis may occur following ophthalmic use.
STORAGE CONDITION
Trysin tablets
should be stored in cool dry place.
INDICATION
Trysin is indicated
for:
v
Resolving
oedema and modulates inflammation associated with various conditions such as
accidental and surgical trauma.
v
Assists
in episiotomies.
v
Neuralgia
with pain radiating into the buttock and lower limb most commonly due to
intervertebral disk herniation.
v
Inflammation
of a vein associated with thrombous formation, known as thrombophlebitis.
v
Gynaecology:- surgery such as vasectomy and caesarean,
Episiotomy, Abdominal Hysterectomy.
v
Bronchitis,
for reduction in viscosity of mucus & sputum formation.
v
Dentistry:- specially for tooth extraction, periapical abscess and maxilofacial
surgery.
v
Fractures
and dislocation
v
Sprains
and strains
v
Opthalmology:-Ocular trauma such as macular oedema, black
eye, hyphema, uveal tract inflammation, sub-conjunctival hemorrhage, extra
ocular trauma.
v
ENT:- Auricular septal hematoma, nasal
fractures, para-pharyngeal abscess.
v
Enhancement
of antibiotic concentration at the site of infection and prevention of
formation of adhesions.
v
Surgery:- Post-operative wound, Oedema & Haematoma, Prevention of
inflammation of the stitch.
DOSAGE AND ADMINISTRATION
Trysin is
administered 1 tablet 4 times a day. The tablet must be taken half an hour
before meal or as directed by the physician.
CONTRAINDICATION
Trysin should not be employed in patients
with severe hepatic insufficiency and should be given cautiously to patient
with renal damage or irregularities of blood clotting mechanism. It should not
be used for a week after pulmonary haemorrhage.
After many years of
wide spread clinical use, there is no reason to believe that proteolytic
enzymes is, or may be teratogenic in humans. However it is sound medical
principle to exercise precautions in prescribing any medication during the
first three months of pregnancy.
SPECIAL PRECAUTIONS
Ocular surgery in
children less than 20 months, congenital cataract, glaucoma, hepatic or renal
diseases, irregularities in blood clotting.
Stimulates tissue
healing
STUDY PROFILE
Proteolytic enzyme (Trysin)
have an excellent safety profile, but there are situation in which they should not
be used. For example, the effects of proteolytic enzymes during pregnancy have
not been sufficiently evaluated. Although no significant side effect has been
noted with any of the proteolytic enzymes, allergic reaction may occur (as with
most therapeutic agents).
Allergies
are triggered by partially undigested protein proteolytic enzymes may
reduce allergic symptoms by further breaking down undigested protein to sizes
that are too small to cause allergic reactions. Limited scientific evidence
supports this theory.proteolytic enzymes such as trypsin and chymotrpsin have anti-inflammatory
activity and may even demonstrate antitumor effects.In one preliminary study of
a pancreatic cancer patients ,the combination of proteolytic enzymes and other
cancer treatments appear to extend survival,despite the fact that most of the
patients died. Proteolytic enzymes may also improve immune system function ,for
example, in
people with shingles (herpes
zoster),though this area of research has not been adequately explored.
ONOCOLOGY
The clinical research that currently exists on proteolytic enzymes
suggests significant benefits in the treatment of many forms of cancer.
Specifically, these studies have shown improvements in the general condition of
patient quality of life and modest to significant improvement in life
expectancy. The studies have considered of patients with cancer of breast, lung,
stomach, head and neck, ovaries, cervix and colon; and lymphomas and multiple
myeloma. These studies involved the use of proteolytic enzyme in conjuction
with conventional therapy (surgery, chemotherapy, and/or radiation) indicating
that proteolytic enzymes can be used safely and effectively with these
treatments.
|
Diagnosis
|
Study design
|
Number
of
Patients
|
Duration
of
therapy
|
Effects of
Enzyme therapy
|
|
abdominal
cancer
|
Prospective
randomized
|
32
vs 25
|
2-44weeks
|
Delay in appearance of metastasis, reduction in tumor size
|
|
Oral
cancer
|
Open
randomized
|
20
vs 19
|
5
weeks
|
Shorter
duration of radiation side effects
|
|
Head
and neck cancers
|
Prospective
randomized
|
47
vs 53
|
At
least 7 weeks
|
Significant
reduction in mouth sores, difficulty in swallowing , &skin reaction
|
|
cervical
cancer
|
Prospective
randomized
|
60
vs 60
|
not
more than 10 weeks
|
Significant
reduction in radiation induced side
effects
|
Clinical studies of
proteolytic enzymes in patients receving radiation therapy
PRESENTATION:
Trysin is available in a blister of
10 Tablets.
Each box of Trysin contains
10 X 10’s
