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Rx
IPCOM
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COMPOSITION:
IPCOM 1 TAB
Each chewable tablet
contains
Iron III hydroxide
Polymaltose Complex equivalent to elemental Iron 100mg
Folic Acid 1mg
DESCRIPTION:
Iron Polymaltose Complex is a polysaccharide-iron
complex, which is a novel iron preparation used in the treatment of iron
deficiency anaemia. Iron, an essential constituent of the body, is necessary
for haemoglobin formation and for the oxidative process of living tissue.
Compiron contains non-ionic ferric iron and polymaltose in a stable complex.
This facilitates a controlled absorption of the ferric iron when it comes in
contact with the mucosal cell surface. Being non-ionic, it does not release any
free radicals and thus takes care of all the toxic effects found due to the
release of free radicals by the traditional ionized iron salt preparations. It
does not interact with the food components and other medications and so, unlike
ferrous salts, there is no decrease in bioavailability of Iron Polymaltose
Complex. This makes sure that with the consumption of this complex, iron gets
utilized at a faster rate in the haemoglobin and myoglobin synthesis. Iron Polymaltose Complex is more
stable than conventional Iron form. Folic acid helps in the proper development
of the baby.
PHARMACODYNAMICS:
Iron is an essential constituent of the body being
necessary for haemoglobin formation and for the oxidative processes of living
tissue.
Iron polymaltose is essentially non-ionic, which
therefore is rapidly absorbed with high rate of iron utilization, producing an
effective increase in hemoglobin . unlike ionised iron salt preparations, it
does not irritate the intestinal mucosa and does not stain the teeth; it has
palatable, non metallic taste.
Folic acid is essential to numerous bodily functions
ranging from nucleotide biosynthesis to the remethylation of homocysteine. It
is especially important during periods of rapid cell division and growth.
During pregnancy, folic acid plays a major role in the prevention of neural
tube defects and other congenital abnormalities. Children and adults require
folic acid to produce healthy red blood cells and prevent anemia.
MODE
OF ACTION
MOUTH:
IPCom
is non-ionic complex and does get ionized in the mouth. Hence there is no
liberation of iron in the mouth. No metallic taste and no teeth staining.
STOMACH:
Since
IPCom is non ionic, the complex does not cause any gastric irritation, no
nausea and vomiting.
DUODENUM:
o
When IPCom comes into contact with the
mucosal proteins in duodenal mucosa, the mucosal proteins namely mucin,
integrin and mobiferin absorbs this ferric iron directly (since it is Ferritin
analogue-body's kind of iron) and transfers this ferric iron to transferrin.
o
The ferric form of iron is transferred
to the Ferritin (bone marrow) through the transferrin.
o
During absorption the iron is absorbed
in ferric form itself (at mucosal proteins), and transferrin and stored in
ferritin.
o
During this entire process there is no
conversion of ferric to ferrous and from ferrous to ferric form and hence no
liberation of electrons.
o
So there is no liberation of electrons
and no side effects caused by electrons like constipation, diarrhoea etc. When
there is no liberation of electrons there is no generation of free radicals.
So
IPCom is called as non-ionic and non-pro-oxidative form of iron
o
The absorption of iron from IPCom is
controlled by a feed-back mechanism and it is called as controlled
Physiological Absorption, which does not cause any iron overload and iron
poisoning.
o
Also IPCom (*since it is non-ionic from)
does not form any complexes with food substances and free from chelate
formation. Hence IPCom can be taken any time (with meal also).
o
Moreover the LD50 values of
IPCom are not achieved even after giving 2000mg elemental iron/kg b.wt.
IPCom chewable tablet contains
folic acid; which is necessary for the maturation of RBC and prevents
megaloblastic anaemia and prevents neural tube defects.
Indications:
·
Treatment of latent iron deficiency and
iron deficiency anaemia including macrocytic anaemia, nutritional anaemia of
infants, anaemia due to excessive haemorrhage and anaemia associated with
infections and malignant disease.
·
Prevention and treatment of iron
deficiency anaemia before, during and after pregnancy and during lactation,
menorrhagia, old age.
·
For prophylactic therapy of iron
deficiency to cover the recommended daily dietary allowances (RDA).
·
Anemia associated with peptic ulcer,
hemorrhoids, hook infestation, post operative traumatic conditions.
CONTRAINDICATIONS:
Iron overload (like in hemochromatosis,
hemosiderosis) or iron use disturbances (like in thalassemia) and in non iron
deficiency anaemias (like hemolytic anaemia) & Hypersensitivity.
Patients receiving repeated blood transfusions.
PRECAUTION
A dark coloration
of the stool may occur which is without clinical significance.
USE IN PREGNANCY AND
LACTATION:
Recommended.
DRUG INTERACTIONS:
No interactions
have been observed. Since, the Iron is complex bound, ionic interaction with foodstuff
components (phytates, oxalates, tannin, etc.) and concomitant administrations
of medicaments (tetracyclines, antacids) are unlikely to occur.
Iron salts appear to reduce the effects of
penicillamine.
Concurrent use with psychotropic drugs may worsen
constipation.
Increased systemic side effects with concomitant ACE
inhibitors and parenteral iron administration has been reported.
SIDE
EFFECTS:
This preparation is well tolerated. However, a
few side effects of oral iron preparations, including nausea, vomiting,
constipation or diarrhoea may occur.
DOSAGE AND ADMINISTRATION:
Up to 3 tablets
daily in divided doses depending on the severity of the anaemia being treated.
The tablets must be chewed.
OVERDOSAGE:
In case of overdosage,
initially epigastric pain, diarrhoea and vomiting can occur and may include
metabolic acidosis, convulsions and coma after apparent recovery. Should seek
emergency medical attention in case of overdose. Initially an emetic should be
given and then gastric lavage and general supportive measures should be
employed.
STORAGE:
Store at a cool & dry place, protected from
light & moisture. Keep out of reach of children.
