|
Rx
Fe-Next
|
COMPOSITION:
Each tablet of
FeNext contains;
Ferrous ascorbate
100mg
Folic acid
1.5mg
DESCRIPTION:
Ferrous Ascorbate
Ferrous
Ascorbate is a synthetic molecule of ascorbic acid and iron. This has fantastic
absorption as ascorbic acid enhances absorption of
iron. Ascorbic acid reduces ferric iron to ferrous
iron which remains soluble even at neutral pH. Studies shown that Ferrous
ascorbate leads to speedy Hemoglobin rise (2.5
- 3.0 gm%) within 30 days and treats iron deficiency anaemia during pregnancy because growing baby needs iron
and takes it supply from the mother. Ferrous
Ascorbate is the world's most widely recognized reference iron with 4 time’s
higher absorption than any other iron form. For
nearly 4 decades, studies on iron preparations have
been benchmarked against Ferrous Ascorbate. Properties of Ferrous Ascorbate are
thus considered the Gold Standard in Iron
therapy. There is no dissociation of Ferrous ascorbatete on entering GI Tract
due to the stable chelate of Iron with
Ascorbate. Also there is no action of food inhibitors as the complex does not dissociate.
Ascorbate is a reducing agent and prevents Oxidation. Thus maintains Iron in
highly soluble ferrous form. With Ferrous
Ascorbate higher absorption leads to less GI disturbance and no interaction
with
food
and can be given any time.
Folic Acid
Folic
acid also known as vit.B9, which is itself not biologically active, but its
biological importance, is due to
tetrahydrofolate and other derivatives after its conversion from dihydrofolic acid in the liver. Folic acid and Folate (the
form naturally occurring in the body) is essential
to numerous bodily functions. The human body needs folate to synthesize DNA,
repair DNA, and methylate DNA as well as to
act as a cofactor in biological reactions involving folate.It is especially
important in aiding rapid cell division and growth, such as in infancy and
pregnancy. Children and adults both require folic
acid to produce healthy red blood cells and prevent
anemia.
CHEMISTRY
The
molecular formula of Ferrous Ascorbate is- C18H21FeO18
Ferrous Ascorbate
There is no dissociation of ferrous
ascorbate on entering GI tract due to the stable chelate of iron with
Ascorbate.Folic acid is mainly absorbed from the proximal part of the small
intestine and is distributed into the body.The principal storage site is the
liver but it is also actively concentrated into the cerebrospinal fluid.There
is an enterohepatic circulation of folate and ultimately it is excreted in the
urine as metabolite.
Advantages of Ascorbate
components of Ferrous Ascorbate
·
Ferrous iron is absorbed 3 times more
than Ferric iron .In the alkaline pH of intestine ,Ferrous iron gets converted
to Ferric hydroxide.
·
Enhanced iron absorption which leads to
higher bioavailability of ferrous ascorbate
a) In case of ferrous
compounds[Ferrous salts]at alkaline pH, Ferrous is rapidly oxidized, resulting
in the formation of large, non-absorbable ferric hydroxide polymers ,which will
attack the gut wall and produces a range of GI symptoms and discomfort
.Addition of ascorbic acid converts ferric form to ferrous form, thus making it
absorbable from duodenum and upper jejunum, resulting in considerable
enhancement of absorption of iron.
b) Even of ferric
iron is generated by the oxidation of ferrous iron, including that from the
dietary source combines with the ascorbates components of ferrous ascorbate to
form a chelate and this complex remain soluble even in alkaline pH of small
intestine
·
Ascorbic is also known to inhibit the
effect of ligands like phytates, tannins, phosphates and polyphenols which
inhibit iron absorption again by the oxidation of ferrous iron.Ascorbate components of Ferrous ascorbate thus has two
fold effects on enhancing the bioavailability of iron:
·
First by inhibiting the oxidation of
Ferrous iron
·
Second by forming soluble complex even
in the alkaline pH of the small intestine
Folic
Acid:
Folic
acid has very high bioavailability, with large oral doses of folic acid
substantially raising
plasma
levels in healthy subjects in a time- and dose-dependent manner. Folic acid is
poorly
transported
to the brain and rapidly cleared from the central nervous system. The primary
methods
of elimination of absorbed folic acid are fecal (through bile) and urine.
INDICATION:
Ø
Iron deficienct Anemia
Ø
Post surgical Convalescence
Ø
Pregnancy &Lactation
Ø
Chronic or Acute blood loss
CONTRAINDICATION:
Patients with history of iron overload or any
known complication of the components like
hemosiderosis, hemochromatosis, hemolytic
anemia.
WARNING & PRECAUTIONS:
Oral iron preparation may aggravate existing
peptic ulcer, regional enteritis and
ulcerative colitis. Patient must be periodically
monitored hematologic and hematinic parameters.
DRUG INTERACTION:
Ferrous ascorbate markedly reduces effect of
Alendronic acid, Alendronate sodium. Ferrous ascorbate absorption may decreased by Aluminium
hydroxide, hydroxyaluminium, Aluminium
hydroxide-magnesium carbonate, aluminium hydroxide-magnesium hydroxide and
calcium.
ADVERSE REACTIONS:
The treatment of neurotic patient was interrupted
because of nausea and regurgitation,In pregnant women the incidence of pyrosis
and chronic constipation is slightly increased.Folic acid is generally well
tolerated but gastrointestinal disturbances
may occur occasionally.Allergic reaction may occur rarely.
DOSAGE:
One tablet once a day. Dose can be increased
to twice daily as per the requirement.
