IVER-DT-6
COMPOSITION
Each dispersible tablet
contains:
Ivermectin 6mg
IVER-DT-12
COMPOSITION
Each dispersible tablet contains:
Ivermectin 12mg
DESCRIPTION
IVER DT contains Ivermectin, is an extremely potent semi synthetic, anthelminthics agent for
oral administration. Ivermectin is derived from the avermectins, a class of
highly active broad spectrum anti-parasitic agents isolated from the
fermentation products of Streptomycin
avermitilis. It has a microfilaricidal action in onchocerciasis and in
lymphatic filariasis and reduces the microfilarial load without the toxicity
seen with diethylcarbamazine.
Pharmacokinetics
Ivermectin is absorbed
from the Gastro-intestinal tract following oral administration with peak plasma
concentration achieved in 4 hours after a single 12mg dose (2×6mg). Ivermectin
is metabolized in liver; the metabolites are excreted exclusively (99%) in the
feces over an estimated period of 12days. The plasma half-life of ivermectin in
man is approximately 18hours following oral administration.
Pharmacodynamics
Ivermectin is a member
of the avermectin class of broad spectrum antiparasitic agents which have a
unique mode of action. Compounds of this class bind selectively and with high
affinity to Glutamate-gated or GABA-gated chloride ion channels which occur in
invertebrate nerve and muscle cells
INDICATIONS
1. Scabies
2. Pediculosis
3. Filariasis
a. Elephantiasis
b. Onchocerciasis (River Blindness)
4. Intestinal Nematode
Infections
a. Strongyloidiasis (Thread worm)
b. Ascariasis (Round worm)
c. Trichuriasis (Whip worm)
d. Enterobiasis (Pin worm)
DOSAGE AND
ADMINISTRATION
A singe dose of 3 to
12mg based roughly on 150µg per kg body-weight by mouth. No food should be
taken before or after the dose. A repeat dose may be given after 10-14 days.
For Scabies, Filaria, Strongyloidiasis and
Pediculosis: 200 mcg/kg body weight.
CONTRAINDICATIONS
Hypersensitivity to any
of the components of this product and in patients with CNS disorders.
ADVERSE EFFECTS
Adverse effects are
usually mild which include nausea, vomiting, constipation, abdominal pain and
fatigue.
DRUG INTERACTION
No any drug interaction
has been reported. On
May 1, the FDA approved safety labeling revisions for ivermectin tablets to
warn of a drug interaction with warfarin. (Stromectol; Merck & Co,
Inc)
PRECAUTIONS
Ivermectin should not
be given to children less than 5 years or to people below 15kgs body weight
& during pregnancy.
PATIENT
INFORMATION
Ivermectin should be
dispersed in about a glass of water. It is better absorbed in empty stomach and
should not be taken concomitantly with meals.
